The translation of preclinical science to anticipate clinical responses is still an unresolved challenge. As a field we made great progress in predicting human pharmacokinetics from preclinical species. However, the translation of drug response from in vitro and in vivo data collected in surrogate systems to the human disease remains challenging. In my presentation I will address how Quantitative Systems Pharmacology  allows us to integrate seemingly disparate data and thus supports drug development via forward- and reverse-translation from preclinical to clinical data.


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